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February 18.2026

2 Minutes Read

Mood Changes in Perimenopause: Understanding Their Impact on Women with Depression History

Illustrated brain with tangled thought bubble, mood changes in perimenopause.

Understanding Mood Changes During Perimenopause

Women in midlife often experience significant hormonal changes that can impact their emotional health. Perimenopause, the transitional phase leading to menopause, commonly involves fluctuations in estrogen levels that can lead to heightened mood instability. For individuals with a history of depression, these changes may prove to be particularly challenging. Around 20% of women experience depressive symptoms during this time, and those with a previous history of depression may see increased intensity in their mood changes.

The Link Between Hormones and Mental Health

Estrogens play a neuroprotective role and have been shown to have antidepressant effects; therefore, when levels fluctuate significantly during perimenopause, many experience not just physical symptoms like hot flashes but also emotional ones. Research indicates that women facing these hormonal shifts are more susceptible to mood disturbances and anxiety, which can dramatically affect their overall quality of life.

Statistics Highlighting Increased Risk

Studies illustrate the prevalence of mood changes during perimenopause. The Penn Ovarian Aging Study found that women were four times more likely to show significant depression scores during perimenopause compared to when they were premenopausal. Moreover, a more recent review indicates that women during perimenopause are 1.4 times as likely to experience depressive symptoms compared to their premenopausal counterparts, emphasizing the importance of awareness in this phase of life.

Recognizing Symptoms and Seeking Help

Identifying perimenopausal depression can be complicated, as the symptoms resemble those of PMS but can occur irregularly and without a clear pattern. Symptoms may include irritability, low energy, tearfulness, and difficulty concentrating. It’s crucial for women experiencing these symptoms to consult healthcare providers to determine the best path forward, whether through lifestyle changes, therapy, or medication.

The Importance of a Holistic Approach

Addressing mental health during perimenopause requires a holistic approach. This includes maintaining open communication with healthcare providers, adopting stress-reducing techniques like mindfulness or yoga, engaging in proper sleep hygiene, and staying active. By understanding the connection between hormonal changes and emotional health, women can better navigate this complex multi-dimensional transition.

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Mood Changes in Perimenopause: Understanding Their Impact on Women with Depression History

Understanding Mood Changes During Perimenopause

The Link Between Hormones and Mental Health

Statistics Highlighting Increased Risk

Recognizing Symptoms and Seeking Help

The Importance of a Holistic Approach

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